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Why is this drug prescribed?

Vardenafil belongs to the class of medications called cyclic GMP-specific phosphodiesterase type 5 inhibitors. These medications work by increasing smooth muscle relaxation and allowing blood to flow into the penis. Vardenafil is used for the treatment of erectile dysfunction (impotence). It helps a man achieve and keep an erection when he is sexually stimulated. Vardenafil does not increase sex drive.

Your doctor may have suggested this medication for conditions other than the ones listed in this drug information article. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor.

How should you take this medication?

The usual starting dose is 10 mg. Your doctor may recommend a dose as low as 5 mg or as high as 20 mg. Swallow the tablet whole with water. It may be taken with or without food. This medication should be taken 25 to 60 minutes before sexual activity. It will usually require 15 to 60 minutes to take effect and may last for four to five hours. Do not take this medication more than once a day.

Because alcohol can make it more difficult to get an erection, do not drink large amounts of alcohol before sexual activity. Moderate amounts of alcohol (two drinks for a 70-kg person) will not interfere with the medication.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones given here, do not change the way you are taking the medication without consulting your doctor.

It is important to use this medication exactly as prescribed by your doctor.

--Storage instructions...

Keep your tablets in the blister pack until it is time to take them. If you take the tablets out of the box or the blister pack they may not keep well.

Keep your tablets in a cool dry place where the temperature stays below 30°C. Do not leave the tablets in the car on hot days. Do not store it or any other medicine in the bathroom or near a sink. Heat and damp can destroy some medicines.

Keep your tablets where children cannot reach them.

What side effects may occur?

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor. If you do experience side effects, your doctor may be able to help you manage them.

The following side effects may go away as your body becomes used to the medication; check with your doctor if they continue or become bothersome.

More common:

• Headache
• Flushing (warm or burning feeling, usually in the face)

Less common:

• Indigestion
• Stuffy nose

Rare:

• Abnormal vision (e.g., decreased vision, blurry vision, increased sensitivity to light, changes in the ability to tell the difference between blue and green)

Contact medical help immediately if any of the following side effects occur:

• You have an erection that lasts longer than four hours (this could permanently damage your penile tissue)
• You have a heart condition and develop chest pains, an irregular heartbeat, or shortness of breath when starting sexual activity
• You have an allergic reaction (e.g., rash; itching; shortness of breath; swollen face, lips, or throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Special warnings about this medication

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if it has not been prescribed by their doctor.

Possible food and drug interactions when taking this medication

Only take vardenafil with other medications if so directed by your doctor.

The following medications may be affected by vardenafil or may increase the risk of side effects:

• Alpha-blockers (e.g., doxazosin, terazosin)
• Anti-arrhythmia (irregular heartbeat) medications (e.g., amiodarone, procainamide, quinidine, sotalol)
• Any medication that contains nitrates (e.g., amyl nitrate poppers, isosorbide mononitrate, isorbide dinitrate, nitroglycerin)
• Erythromycin
• Indinavir
• Itraconazole
• Ketoconazole
• Ritonavir

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• Stop taking one of the medications,
• Change one of the medications to another,
• Change how you are taking one or both of the medications, or
• Leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Special information if you are pregnant or breastfeeding

Vardenafil is not approved for use by women.

Recommended dosage

The starting dose of LEVITRA is 10 mg taken no more than once per day. Your doctor will decide the dose that is right for you. In patients taking alpha blockers, your doctor may start you on a lower dose of LEVITRA. In patients taking certain medications such as ritonavir, indinavir, ketoconazole, itraconazole, and erythromycin, lower doses of LEVITRA are recommended, and time between doses of LEVITRA may need to be extended.

Overdosage

Immediately telephone your doctor, or the Poisons Information Centre, or go to the accident and emergency department at your nearest hospital, if you think you or anyone else may have taken too much LEVITRA. Do this even if there are no signs of discomfort or poisoning.

You may need urgent medical attention.