Buy Detrol (Tolterodine L-tartrate) and other pharmacy medication online at www.dispensarymeds.com

Why is this drug prescribed?

Detrusitol is used to treat symptoms of an overactive bladder, for example urinary frequency, urgency or incontinence.

Detrusitol belongs to a group of medicines called antispasmodics. It helps to control the release of urine by reducing spasm, and relaxing the smooth muscle of the bladder wall.

It also increases the storage volume of the bladder, and can act on the brain to delay the desire to urinate.

How should you take this medication?

Follow all directions given to you by your doctor or pharmacist carefully.

They may differ from the information contained in this leaflet.

If you do not understand the instructions on the label, ask your doctor or pharmacist for help.

Swallow the tablets whole with a full glass of water.

Take your medicine at about the same time each day.

Taking Detrusitol at the same time each day will have the best effect. It will also help you remember when to take it.

It does not matter if you take Detrusitol before or after food.

Continue taking your medicine for as long as your doctor tells you.

This medicine helps to control your condition, but does not cure it. It is important to keep taking your medicine even if you feel well.

Your doctor should re-assess your condition at regular intervals, for example after 6 months, to determine how long you need to keep taking Detrusitol for.

--If you miss a dose...

If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to.

Otherwise, take it as soon as you remember, and then go back to taking your medicine as you would normally.

Do not try to make up for missed doses by taking more than one dose at a time.

This may increase the chance of you getting an unwanted side effect.

If you are not sure what to do, ask your doctor or pharmacist.

--Storage instructions...

Keep your tablets in the blister until it is time to take them.

If you take the tablets out of the blister they may not keep well.

Keep your tablets in a cool dry place where the temperature stays below 25°C.

Do not store Detrusitol or any other medicine in the bathroom or near a sink. Do not leave it on a windowsill or in the car.

Heat and dampness can destroy some medicines.

Keep Detrusitol where children cannot reach it.

What side effects may occur?

Do not be alarmed by the following lists of possible side effects. You may not experience any of them.

Ask your doctor or pharmacist to answer any questions you may have.

Tell your doctor or pharmacist if you notice any of the following and they worry you:

• Dry mouth
• Heartburn
• Headache
• Constipation, stomach pain or diarrhoea
• Dry eyes
• Nausea
• Tiredness
• Swollen ankles

Tell your doctor immediately if you notice any of the following:

• Swelling of the face, lips, mouth, tongue or throat which may cause difficulty in swallowing or breathing
• Dizziness or confusion
• Fits
• Fast heartbeat or palpitations
• Shortness of breath and swelling of the feet or legs
• Blurred vision
• Difficulty or pain in urinating (passing water)
• Hallucinations (seeing, hearing or feeling things that are not really there)

Tell your doctor or pharmacist if you notice anything that is making you feel unwell.

Other side effects not listed above may also occur in some people.

Possible food and drug interactions when taking this medication

Tell your doctor or pharmacist if you are taking any other medicines, including medicines that you buy without a prescription from a pharmacy, supermarket or health food shop.

Some medicines and Detrusitol may interfere with each other. These include:

• some medicines used to treat depression such as: fluoxetine, amitriptyline
• certain medicines used to treat irregular heart beats: flecainide, quinidine, procainamide, disopyramide, sotalol, amiodarone
• some antifungals: fluconazole, ketoconazole, itraconazole, miconazole
• some antibiotics: erythromycin, clarithromycin
• cisapride, a medicine used to treat heartburn/reflux and related intestinal disorders
• metoclopramide, a medicine used to treat nausea and gastric retention
• tranquillisers, such as: haloperidol, chlorpromazine, thioridazine, pimozide
• anti-proteases, medicines used to treat HIV infection, such as: ritonavir, indinavir
• droperidol, a medicine used to prevent or reduce nausea and vomiting

These medicines may be affected by Detrusitol or may affect how well it works. You may need different amounts of your medicines, or you may need to take different medicines.

Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking Detrusitol.

Special information if you are pregnant or breastfeeding

Studies in pregnant mice have shown that high doses of tolterodine caused reduced foetal weight, embryolethality and increased incidence of foetal malformations. There are no studies in pregnant women. Therefore, tolterodine should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus.

Use of tolterodine during lactation should be avoided since no data on excretion into breast milk in humans are available.

Recommended dosage

The recommended dose is 2mg b.i.d. In the case of troublesome side-effects the dose may be reduced from 2mg to 1mg b.i.d.

The recommended dose is 1mg b.i.d. for patients with impaired renal function, impaired liver function, or receiving concomitant ketoconazole or other potent CYP3A inhibitors.

After six months the need for further treatment should be considered.

Safety and effectiveness in children have not been established.

Overdosage

The highest dose of tolterodine tartrate given to human volunteers was 12.8mg as a single dose. The most severe adverse events observed were accommodation disturbances and micturition difficulties.

Overdosage with tolterodine can potentially result in severe central antimuscarinic effects and should be treated accordingly.

A small increase in QTc interval was observed at a total daily dose of 8mg, twice the recommended daily dose. In the event of overdosage with tolterodine, standard supportive measures for managing QT interval prolongation should be adopted.